线粒体调亡信号通路图

Survival Factors:Growth Factors,Cytokines, etc.FasLFas/CD95FADDDeath Stimuli:

Survival Factor WithdrawalCaspase-8,-10PI3KBidMuleMicrotubulesLC8BimLC8Mcl-1Bcl-xLtBidBimBcl-2HrkDP5Erk1/2PKCPKAp90RSKJNKHrkDP5JNKAktp70 S6KBakBaktBidBaxBcl-2BaxBaxBcl-2NoxaPumaBcl-2[NAD]SIRT2Mulep5314-3-3BadCalcineurinCAMKIIBaxBaxBadCaspase-2RAIDDPIDD14-3-3BadCytosolicSequestrationHSP60Bcl-2 FamilyPro-ApoptoticPro-SurvivalCaspase-3ubBcl-xLApaf-1Caspase-9Cyto cHtrA2XIAPSmac/DiabloMcl-1Endo GAIFATM/ATRING2ApoptosisDNA damageGenotoxic Stress© 2003 - 2008 Cell Signaling Technology, Inc.Apoptosis_Mitochondrial.ai • created February 2003 • revised September 2008

www.cellsignal.comSignaling Pathways Key

KinasePhosphataseTranscription FactorCaspaseReceptorEnzymeCyclin, pro-apoptoticpro-survivalGAP / GEFGTPaseG-protein, ribosomal subunitDirect Stimulatory ModificationDirect Inhibitory ModificationMultistep Stimulatory ModificationMultistep Inhibitory ModificationTentative Stimulatory ModificationTentative Inhibitory ModificationTranscriptional StimulationTranscriptional InhibitionTranslocationSeparation of Subunits or Cleavage ProductsJoining of Subunits© 2003 - 2009 Cell Signaling Technology, Inc.