PROCESS AND INTERMEDIATES FOR THE PREPARATION OF A

专利名称：PROCESS AND INTERMEDIATES FOR THE

PREPARATION OF A TRIAZOLINE HERBICIDE

发明人：CRISPINO, Gerard,GOUDAR, Jaidev, S.申请号：EP953627.1申请日：19981016公开号：EP1036068A1公开日：20000920

摘要：A process for preparing an alkyl α-2-chloro-5- [4-(difluoromethyl)-4,5- dihydro-3-methyl-5- oxo-1H-1,2,4-triazol -1-yl]-2,4-substituted -benzene-propanoate herbicide,by reacting an alkyl α-acetyl-5- [4-(difluoromethyl)-4,5- dihydro-3-methyl-5- oxo-1H-1,2,4-triazol -1-yl]-2,4-disubstituted -benzene-propanoate, Intermediate D, first withsodium hypochlorite, then with a base, and recovering the herbicide. Intermediate D isprepared by reacting a 1-(2,4-disubstituted-5- halophenyl)-4-difluoromethyl-4, 5-dihydro-3-methyl-5- oxo-1H-1,2,4-triazole, Intermediate B, with an alkyl alkanoate in thepresence of a palladium catalyst and a tertiary amine. Intermediate B is prepared byreacting a 1-(2,4-disubstituted- phenyl)-4-difluoromethyl-4, 5-dihydro-3-methyl-5- oxo-1H-1,2,4-triazole with a halogenating agent in the presence of an acid. The 2,4-substituents are independently selected from halo, alkyl, cycloalkyl, alkoxy, nitro, orhetercyclyl.

申请人：FMC CORPORATION

地址：1735 Market Street Philadelphia, PA 19103 US

国籍：US

代理机构：W.P. Thompson & Co.

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