Determination of 5-ASA efficacy in CRC prevention

专利名称：Determination of 5-ASA efficacy in CRC

prevention and/or treatment by geneexpression analysis

发明人：Alexis Grande,Sandra Parenti,Fabrizio

Ferrarini

申请号：US12662275申请日：20100408

公开号：US20100261174A1公开日：20101014

专利附图：

摘要：A method is disclosed for the determination of 5-ASA efficacy in preventing

and/or treating CRC in a mammalian, which comprises the analysis of the inhibition of theβ-catenin pathway in presence of 5-ASA. More in details, the method comprises

measuring the expression of at least one gene involved in the regulation of the β-cateninsignalling pathway, such as μ-protocadherin, E-cadherin, β-catenin, Axin1, ICAT, p21andthe expression of onco-suppressor genes, such as KLF4 and CEBPα. Gene expression canbe measured in accordance to the methods commonly available in the art such as QRT-PCR and immunohistochemistry.

申请人：Alexis Grande,Sandra Parenti,Fabrizio Ferrarini

地址：Modena IT,Modena IT,Modena IT

国籍：IT,IT,IT

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